Research Progress on the Effect of Sodium Butyrate on Apoptosis and Laboratory Animals

doi:10. 3969 / j. issn. 1006-6179. 2022. 03. 015

Laboratory Animal Science ›› 2022, Vol. 39 ›› Issue (3): 74-78.DOI: 10. 3969 / j. issn. 1006-6179. 2022. 03. 015

( College of Veterinary Medicine, China Agricultural University, Beijing 100193,China)

Received:2020-06-30 Online:2022-06-28 Published:2022-07-15

丁酸钠对细胞凋亡和实验动物影响的研究进展

(中国农业大学动物医学院,北京 100193)

通讯作者: 周向梅( 1973—) ,女,博士,教授,主要从事动物结核病防治研究 Email;zhouxm@ cau. edu. cn
作者简介:王浩然( 1996—) ,男,硕士研究生,研究方向:主要从事动物结核病防治研究,Email;475354396@ qq. com
基金资助:
国家自然科学基金(31873005)

Abstract

Abstract: Sodium butyrate is processed into sodium salt form of butyric acid. Sodium butyrate has the effects of anti-inflammation, improving immunity, stabilizing gut microbiota, etc. In this paper, in combination with the research progress at home and abroad in recent years, it focuses on the induction of body cells induced by sodium butyrate. The specific mechanism of apoptosis includes sodium butyrate activating death receptor pathway, mitochondrial pathway and endoplasmic reticulum stress pathway. The reasons why mechanism of sodium butyrate in improving animal model of disease was discussed. Hope to provide new ideas for sodium butyrate in disease prevention and treatment.

Key words: sodium butyrate, apoptosis, laboratory animals, influence factor

摘要： 丁酸钠是丁酸加工成钠盐形式,丁酸钠具有抗感染、提高机体免疫力、稳定肠道菌群等功效,文中结合近年来国内外的研究进展,重点总结了丁酸钠诱导机体细胞凋亡的具体机制,包括丁酸钠激活死亡受体通路、线粒体通路和内质网应激通路等。并探讨了丁酸钠改善疾病动物模型的具体机制。希望为丁酸钠在疾病预防和治疗中提供新的思路。

关键词: 丁酸钠, 凋亡, 实验动物, 影响因素

CLC Number:

Q95-3

WANG Haoran, LIAO Yi, YAO Jiao, ZHAO Deming, ZHOU Xiangmei. Research Progress on the Effect of Sodium Butyrate on Apoptosis and Laboratory Animals[J]. Laboratory Animal Science, 2022, 39(3): 74-78.

王浩然, 廖轶, 姚娇, 赵德明, 周向梅. 丁酸钠对细胞凋亡和实验动物影响的研究进展[J]. 实验动物科学, 2022, 39(3): 74-78.

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